Beyond Lesson Studies and Design Experiments: Using theoretical tools in practice and finding out how they work

This paper aims to illustrate how fruitful insights into the link between school teaching practice and student learning outcomes can be theoretically grounded by the variation theory from the field of phenomenography; and from this framework demonstrate how a 'pedagogy of awareness' can be implemented in the classroom. In this study, five teachers and 162 students at Primary Four level of school education in Hong Kong participated and the practice of the 'learning study' was adopted. By comparing the results of pre- and posttests, a significant gain was observed in the students learning outcomes.

Simulation of an all-optical 1 x 2 SMZ switch with a high contrast ratio

Abstract — An all-optical 1×2 high contrast ratio (CR) switch based on the symmetric Mach-Zehnder (SMZ) interferometers is presented. Simulation results show a remarkable improvement of the inter-output CR (~25 dB) between the two outputs compared with an existing SMZ switch. It is shown that the proposed switch offers high values of inter-output CR (> 32dB) over a wide range of input powers using appropriate power of the control pulses. I

Defense against Adversarial Attacks Using High-Level Representation Guided Denoiser

Neural networks are vulnerable to adversarial examples, which poses a threat to their application in security sensitive systems. We propose high-level representation guided denoiser (HGD) as a defense for image classification. Standard denoiser suffers from the error amplification effect, in which small residual adversarial noise is progressively amplified and leads to wrong classifications. HGD overcomes this problem by using a loss function defined as the difference between the target model's outputs activated by the clean image and denoised image. Compared with ensemble adversarial training which is the state-of-the-art defending method on large images, HGD has three advantages. First, with HGD as a defense, the target model is more robust to either white-box or black-box adversarial attacks. Second, HGD can be trained on a small subset of the images and generalizes well to other images and unseen classes. Third, HGD can be transferred to defend models other than the one guiding it. In NIPS competition on defense against adversarial attacks, our HGD solution won the first place and outperformed other models by a large margin

Incorporation of aptamers in the terminal loop of shRNAs yields an effective and novel combinatorial targeting strategy.

Gene therapy by engineering patient's own blood cells to confer HIV resistance can potentially lead to a functional cure for AIDS. Toward this goal, we have previously developed an anti-HIV lentivirus vector that deploys a combination of shRNA, ribozyme and RNA decoy. To further improve this therapeutic vector against viral escape, we sought an additional reagent to target HIV integrase. Here, we report the development of a new strategy for selection and expression of aptamer for gene therapy. We developed a SELEX protocol (multi-tag SELEX) for selecting RNA aptamers against proteins with low solubility or stability, such as integrase. More importantly, we expressed these aptamers in vivo by incorporating them in the terminal loop of shRNAs. This novel strategy allowed efficient expression of the shRNA-aptamer fusions that targeted RNAs and proteins simultaneously. Expressed shRNA-aptamer fusions targeting HIV integrase or reverse transcriptase inhibited HIV replication in cell cultures. Viral inhibition was further enhanced by combining an anti-integrase aptamer with an anti-HIV Tat-Rev shRNA. This construct exhibited efficacy comparable to that of integrase inhibitor Raltegravir. Our strategy for the selection and expression of RNA aptamers can potentially extend to other gene therapy applications

Optimisation of the key SOA parameters for amplification and switching

Wireless Sensor Networks (WSN) are composed of small, low cost, resource-constrained computing nodes equipped with low power wireless transceivers. Generally, they are embedded in their environment to perform some specific monitoring and/or control function. Unlike wired networks that have dedicated routers for network connectivity and message forwarding, every node in a WSN can act as a router in a multi-hop network. A WSN can offer a cheap, applicationspecific solution in a variety of situations including military and disaster response scenarios, where other approaches are not viable. Due to their unattended nature and deployment in possibly hostile environmental conditions, there are many challenges in ensuring that a WSN is formed effectively and survives long enough to fulfil its function. Securing a WSN against attack is a particular challenge. Traditional encryption mechanisms are resource hungry and are not sufficient alone to provide a complete solution. This project is concerned with secure routing protocols. Formal methods are used to model and analyse the design of existing protocols and to demonstrate some previously unreported weaknesses

Thermodynamics of Dual CFTs for Kerr-AdS Black Holes

Recently Gibbons {\it et al.} in hep-th/0408217 defined a set of conserved quantities for Kerr-AdS black holes with the maximal number of rotation parameters in arbitrary dimension. This set of conserved quantities is defined with respect to a frame which is non-rotating at infinity. On the other hand, there is another set of conserved quantities for Kerr-AdS black holes, defined by Hawking {\it et al.} in hep-th/9811056, which is measured relative to a frame rotating at infinity. Gibbons {\it et al.} explicitly showed that the quantities defined by them satisfy the first law of black hole thermodynamics, while those quantities defined by Hawking {\it et al.} do not obey the first law. In this paper we discuss thermodynamics of dual CFTs to the Kerr-AdS black holes by mapping the bulk thermodynamic quantities to the boundary of the AdS space. We find that thermodynamic quantities of dual CFTs satisfy the first law of thermodynamics and Cardy-Verlinde formula only when these thermodynamic quantities result from the set of bulk quantities given by Hawking {\it et al.}. We discuss the implication of our results.Comment: Revtex4, twocolumn, 6 pages, v2: 7 pages, more references and comments added, an err correcte